Our Objective
Our major goal is to identify unique signaling networks within individual
tumor lineages that mediate tumor growth. We place our emphasis on the
integration of the individual life science and information science disciplines
as
well as the translation of the results into therapeutic strategies for the
treatment of cancer patients. Our project aims to answer three major questions:
Genomic Data
How can we integrate genomic data to understand
lineage-specific
signaling dependencies of transcriptional regulators?
Large Scale Data Handling
How can we enable efficient and secure large-scale data
handling to study medical datasets in a multi-disciplinary environment?
Dependency Dissection
How can we dissect lineage-specific signaling dependencies
of transcriptional
regulators on a molecular level?
Identification of Unique Signaling Networks That
Mediate Tumor Growth
The junior group leader alliance "MILES —
Multi-Disciplinary
Identification of
Lineage-
Specific Signaling Dependencies in Cancer"
is a consortium funded by the Federal Ministry of Education and Research (BMBF)
within the e:Med call that promotes systems-oriented research into diseases
and preventive measures by linking life sciences with information sciences.
It consists of 5 sub-project leaders who are all part of the University of Cologne.
