Multi-Disciplinary Identification of Lineage-Specific Signaling Dependencies in Cancer

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Our Objective

Our major goal is to identify unique signaling networks within individual tumor lineages that mediate tumor growth. We place our emphasis on the integration of the individual life science and information science disciplines as well as the translation of the results into therapeutic strategies for the treatment of cancer patients. Our project aims to answer three major questions:

Genomic Data

How can we integrate genomic data to understand lineage-specific signaling dependencies of transcriptional regulators?

Large Scale Data Handling

How can we enable efficient and secure large-scale data handling to study medical datasets in a multi-disciplinary environment?

Dependency Dissection

How can we dissect lineage-specific signaling dependencies of transcriptional regulators on a molecular level?

Identification of Unique Signaling Networks That Mediate Tumor Growth

The junior group leader alliance "MILESMulti-Disciplinary Identification of Lineage- Specific Signaling Dependencies in Cancer" is a consortium funded by the Federal Ministry of Education and Research (BMBF) within the e:Med call that promotes systems-oriented research into diseases and preventive measures by linking life sciences with information sciences. It consists of 5 sub-project leaders who are all part of the University of Cologne.